Is it possible to develop a tolerance to cannabidiol and similar medications?
It’s not a big surprise that tolerance to various medical substances is very common. And CBD is not an exception. This means that patients may become tolerant to CBD over time if cannabidiol is the substance that the body can easily get used to.
But, the answer to the question isn’t just “yes,” but both “yes” and “no” are the responses. How is it possible?
The two primary active ingredients of medicinal cannabis – THC and CBD – have different tolerance profiles, which explains this. THC tolerance will increase with repeated medicinal cannabis usage, but this isn’t always the case with cannabidiol.
For additional information about cannabis tolerance and how we can reduce it, keep reading this Happy Garden article.
Time by time, your body gets used to the medication or substance you take, so tolerance involves requiring greater dosages to provide the same results as when you first felt it.
For instance, if you are an active coffee drinker, you should know how it slowly loses its effects. In this case, chances are that you’ll need to consume more of the beverage to have the same benefits as when it initially began.
But why does the body initially develop a tolerance to substances?
Maintaining homeostasis within your body is your body’s main goal. It doesn’t matter whether it’s a scientifically tested medication or some unfamiliar substance, when a foreign material gets into our organism, the body processes it and starts making efforts to return to equilibrium.
This also explains why individuals who regularly use alcohol frequently build a high tolerance over time because their systems get increasingly skilled at regulating the chemical imbalance.
The endocannabinoid system is especially affected by CBD. It has more of an indirect effect on CB1 and CB2 receptors than direct binding. The neuroprotective properties of cannabidiol are unaffected by CB1 inhibition, indicating that it doesn’t bind to the receptor directly and, therefore, shouldn’t theoretically cause tolerance to develop.
However, CBD can increase the body’s synthesis of endocannabinoids and enhance the binding affinity of certain receptors by a different method. Through this approach, cannabidiol aids the endocannabinoid system in preserving equilibrium between all important bodily functions.
Cannabidiol improves the functioning of the endocannabinoid system by adjusting the activity of its receptors and assuring more effective use of the body’s cannabinoids, as opposed to driving it to become hyperactive and less receptive to the substance over time. So, it’s not tolerance that might cause the disappearance of CBD’s effects.
It is also critical to keep in mind that everyone develops tolerance to substances at a different rate, and this variability should be taken into account, Because every one of us has a different biological structure, our physiologies also vary.
The way the body responds to a particular drug’s presence or absence determines the difference between tolerance and dependency.
When a person develops tolerance, particular bodily cell receptors that light up when a medication is a present stop acting as they previously did. As a result, the drug may be eliminated from your system more quickly.
While with dependency, you can feel withdrawal if the substance is absent or if the dose is abruptly decreased, so it’s getting harder and harder to be able to give up the substance since you become dependent. And guess what?
This indicates that our body can function normally only when the medicine is present. Numerous medicines carry the risk of dependence, so you always need to check the possible side effects of the medications you take.
Addiction differs from tolerance and dependence, though, since it is a much more difficult state of the body.
Building a tolerance to any chemical is a well-known idea for everyone. Many of us encounter it in our daily lives. When you drink coffee or tea, especially if you do so every day, you need a higher dose over time to maintain the same level of attention and energy as you did, say, a few months ago.
If CBD does carry the danger of tolerance development, it should adhere to certain processes used by the majority of supplements and pharmaceuticals.
Even though there are many more factors involved in tolerance than simply these three pathways, the research to date seems to indicate that CBD does not cause tolerance.
Instead, it can reduce CB1 receptor activation without the endocannabinoid system needing to become less sensitive. This interaction holds enormous promise since the compound could be able to mitigate the adverse effects and tolerance-inducing properties of other cannabinoids.
As we stated before, it is still difficult to provide a conclusive explanation for how CBD affects the development of tolerance. Much more study is required since there are so many variables that affect how quickly we develop tolerance.
According to what we know right now, the answer is unclear. Consistent CBD usage may result in a reduction in the amount of substance required over time to experience the same effect. It seems that we don’t need to be concerned about cannabidiol tolerance at this time when we take into account the fact that the substance actively promotes various other important ECS activities.
Let’s first get to know the phenomenon of reverse tolerance.
Within the CBD community, this phenomenon is quite well recognized, meaning that too much cannabidiol over time may indicate that you need less of the substance to achieve the same outcomes. This is because long-term regular usage of it might increase your sensitivity to the substance.
However, we need to always remember that everyone’s body is different and will have different effects. The occurrence of reverse tolerance may be a sign that your cannabinoid receptors are active and that the CBD has increased their efficiency.
If this has happened, you will need to take less cannabidiol to get the same health advantages. You may benefit from occasional pauses in CBD usage if you get tolerant to it in this way.
Patients can indeed become tolerant to THC. Continuous and excessive THC usage will lead to tolerance-building just like other drugs and chemicals.
How does it happen? Consuming THC causes it to attach to CB1 receptors, which are mostly found in the brain. These CB1 receptors become more resilient and start to suppress the effects of THC to maintain equilibrium after frequent THC use.
In other words, your body gets better and more effective at handling THC the more of it you take, and that’s how you build up a tolerance to the substance.
However, THC may be more dangerous since it can cause addiction, so always check out your cannabidiol products to ensure they contain less than 0.3% THC, and consult with your doctor to avoid unnecessary consumption of the substance.
Cannabidiol is a non-psychoactive substance. Unlike tetrahydrocannabinol, which gets you “high,” this active substance is being studied for a variety of potential medicinal advantages, so to fully use the benefits CBD has, you must reduce your tolerance to the substance.
We suggest you record your dosage, how you feel before and after each dose, as well as any changes in your symptoms that you detect. If you notice that it’s no longer functioning as effectively after some time, consider taking a few days off to reset your system.
Before using CBD to treat a medical issue, check with your doctor to see whether it’s a good fit for you, especially if you’re also on other drugs. Numerous over-the-counter, prescription and dietary products may interact with it.
When it comes to developing your tolerance, you have two choices to take into account:
Firstly, stop using your CBD for a few days. Your body will have enough time to adjust without any saturation. Continue cannabidiol supplementation at a lower dose after this time has passed. This period can last 2-3 days for effectiveness.
There is also a second option, also known as “titration”, every three days. Cut back on your normal dosage by 25%. By gradually reducing what your body has been accustomed to over time, titration increases your tolerance to CBD. The notion is that your body’s tolerance to it will decrease after this titration period.
The second alternative calls for greater perseverance and careful attention to detail.
According to 2017 research, people might tolerate up to 1,500 mg per day without harm.
However, this dosage isn’t universal and it might be difficult to determine the ideal CBD dose since every person has a distinct quantity that is acceptable for them because their biology and reactions are varied.
How do you decide what is best for you?
The answer is to find your best CBD dose by starting with a low dose and gradually increasing it over time until you feel like you have reached the best dose for you.
Remember, excessive CBD usage might cause your body to get tolerant to it just like any other chemical. However, it is difficult to research how this substance impacts tolerance, though, because of the way that it uniquely interacts with cannabinoid receptors.
It’s doubtful that an increased intolerance is the cause of your CBD oil’s failure to function. Although factors like age, weight, and metabolism may cause your threshold to fluctuate over time, the quality of the product is typically the culprit.
Inflammation, PTSD, depression, and many other disorders may find relief from cannabidiol products, which don’t lead to drug dependence or intoxication. All you need to do is to make sure you get CBD oil from a reliable provider like Happy Garden since the quality of your product can determine every single health outcome.
Why should you trust Happy Garden?
